INDUCIBLE CRISPR ACTIVATION SCREEN FOR INTERFERON-STIMULATED GENES IDENTIFIES OAS1 AS A SARS-COV-2 RESTRICTION FACTOR.

Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor.

Interferons establish an antiviral state through the induction of hundreds of interferon-stimulated genes (ISGs).The mechanisms and viral specificities for most ISGs remain incompletely understood.To enable Pasture Lamp high-throughput interrogation of ISG antiviral functions in pooled genetic screens while mitigating potentially confounding effect

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Advancements in Applications of Natural Wool Fiber: Review

Natural fibers are getting attention from researchers and academician for utilization in new technology due to their ecofriendly nature and sustainability.This paper reviews advancements of utilization of natural wool fiber in industry and agriculture.Sheep wool is one of the natural and renewable sources which is widely used in the textile industr

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Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells

Previous studies suggest that the presence of antigen-specific polyfunctional T cells is correlated with improved pathogen clearance, disease control, and clinical outcomes; however, the molecular mechanisms responsible for the generation, function, and survival of polyfunctional T cells remain unknown.The study of polyfunctional T cells has been,

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Proposal of the five points support method for suppressing vibration transmission from compressor to refrigerator

In order to reduce the power consumption of the household refrigerator further, it is necessary to control the rotation frequency of a reciprocating compressor as low as possible.However, several natural frequencies of the compressor exist in the low rotation frequency region.Therefore, the resonance occur in the compressor due to the unbalance for

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